Protegemos tu salud a través de la Ciencia
Investigación
Enfermedades tropicales y olvidadas
Líneas de investigación
Contenidos con Investigacion .
El Centro nacional de Medicina Tropical tiene como base la investigación en aspectos epidemiológicos, de diagnóstico, tratamiento y control de las siguientes enfermedades infecciosas:
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Malaria
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Enfermedad de chagas
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Tripanosomiasis humana africana
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Oncocercosis y otras filariasis
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VIH y sus enfermedades oportunistas
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Tuberculosis
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Leishmaniasis
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Otras enfermedades desatendidas
El Centro Nacional de Medicina Tropical cuenta con un laboratorio de malaria y biología molecular en el que se realizan estudios de variabilidad genética de los parásitos, resistencia a fármacos y estudios de entomología molecular.
Al mismo tiempo, el CNMT aborda estudios sobre desigualdades sociales en salud. Parte de la base de que la enfermedad está determinada por la estructura social, política y económica en la que se vive. Por lo tanto estudia la salud y la enfermedad como fenómeno colectivo y no como el resultado de factores de riesgo individual. Dentro de esta línea se abordan los determinantes sociales que predispone a los individuos y poblaciones más desfavorecidas a desarrollar las enfermedades anteriormente descritas.
También es objeto de estudio la salud de la población inmigrante en España, abordando fundamentalmente las enfermedades infecciosas (tuberculosis, VIH/sida, enfermedad de Chagas) y el acceso y utilización de los servicios de salud.
Proyectos de investigación
Contenidos con Investigacion .
El Centro Nacional de MedicinaTropical trabaja actualmente en los siguientes proyectos:
- Verificación de la interrupción de la transmisión de la oncocercosis en la isla de Bioko, Guinea Ecuatorial, financiado por la Task Force NTDs.
- Estudio de eficacia terapéutica de la primera y segunda línea de tratamiento, artesunato / amodiaquina y artemeter/ lumefantrina, de Guinea Ecuatorial, financiado por la OMS
- Caracterización funcional de la MBL (Mannose-Binding Lectin) de T. brucei gambiense implicada en la resistencia al suero humano financiado por las AES.
- Accesibilidad y utilización de servicios sanitarios para el diagnóstico de la enfermedad de Chagas en la Comunidad Autónoma de Madrid, financiado por la AESI.
- Mutaciones de resistencia a antimaláricos en Guinea Ecuatorial y Etiopía: diferencias en áreas con distinta endemicidad de malaria, financiado por la AESI.
- Estudio de la línea base de la malaria en Guinea Ecuatorial, financiado por la AECID.
Publicaciones destacadas
Determinants of delay in malaria care-seeking behaviour for children 15 years and under in Bata district, Equatorial Guinea.
Determinants of delay in malaria care-seeking behaviour for children 15 years and under in Bata district, Equatorial Guinea. Romay-Barja M, Cano J, Ncogo P, Nseng G, Santana-Morales MA, Valladares B, Riloha M, Benito A. Malar J. 2016 Mar 31;15:187. doi: 10.1186/s12936-016-1239-0.
PUBMED DOIMalaria prevalence in Bata district, Equatorial Guinea: a cross-sectional study
Malaria prevalence in Bata district, Equatorial Guinea: a cross-sectional study. Ncogo P, Herrador Z, Romay-Barja M, García-Carrasco E, Nseng G, Berzosa P, Santana-Morales MA, Riloha M, Aparicio P, Valladares B, Benito A. Malar J. 2015 Nov 16;14:456. doi: 10.1186/s12936-015-0986-7.
PUBMED DOIMultidrug-resistant and heteroresistant Mycobacterium tuberculosis and associated gene mutations in Ethiopia
Multidrug-resistant and heteroresistant Mycobacterium tuberculosis and associated gene mutations in Ethiopia. Mekonnen D, Admassu A, Mulu W, Amor A, Benito A, Gelaye W, Biadglegne F, Abera B. Int J Infect Dis. 2015 Oct;39:34-8. doi: 10.1016/j.ijid.2015.06.013. Epub 2015 Jun 25.
PUBMED DOIHIV-1 variability and viral load technique could lead to false positive HIV-1 detection and to erroneous viral quantification in infected specimens
HIV-1 variability and viral load technique could lead to false positive HIV-1 detection and to erroneous viral quantification in infected specimens. Álvarez P, Martín L, Prieto L, Obiang J, Vargas A, Avedillo P, Rojo P, Fernández McPhee C, Benito A, Ramos JT, Holguín Á. J Infect. 2015 Sep;71(3):368-76. doi: 10.1016/j.jinf.2015.05.011. Epub 2015 May 29.
PUBMED DOIQuality of malaria diagnosis and molecular confirmation of Plasmodium ovale curtisi in a rural area of the southeastern region of Ethiopia.
Quality of malaria diagnosis and molecular confirmation of Plasmodium ovale curtisi in a rural area of the southeastern region of Ethiopia. Díaz PB, Lozano PM, Rincón JM, García L, Reyes F, Llanes AB. Malar J. 2015 Sep 18;14(1):357. doi: 10.1186/s12936-015-0893-y.
PUBMED DOIEconomic evaluation of Chagas disease screening in Spain.
Economic evaluation of Chagas disease screening in Spain. Imaz-Iglesia I, Miguel LG, Ayala-Morillas LE, García-Pérez L, González-Enríquez J, Blasco-Hernández T, Martín-Águeda MB, Sarría-Santamera A. Acta Trop. 2015 Aug;148:77-88. doi: 10.1016/j.actatropica.2015.04.014. Epub 2015 Apr 25.
PUBMED DOIRural-Urban Differences in Household Treatment-Seeking Behaviour for Suspected Malaria in Children at Bata District, Equatorial Guinea
Rural-Urban Differences in Household Treatment-Seeking Behaviour for Suspected Malaria in Children at Bata District, Equatorial Guinea. Romay-Barja M, Jarrin I, Ncogo P, Nseng G, Sagrado MJ, Santana-Morales MA, Aparicio P, Valladares B, Riloha M, Benito A. PLoS One. 2015 Aug 18;10(8):e0135887. doi: 10.1371/journal.pone.0135887. eCollection 2015.
PUBMED DOIMolecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea
Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea. Cordón-Obras C, Rodríguez YF, Fernández-Martínez A, Cano J, Ndong-Mabale N, Ncogo-Ada P, Ndongo-Asumu P, Aparicio P, Navarro M, Benito A, Bart JM. Front Microbiol. 2015 Jul 24;6:765. doi: 10.3389/fmicb.2015.00765. eCollection 2015.
PUBMED DOILow Dietary Diversity and Intake of Animal Source Foods among School Aged Children in Libo Kemkem and Fogera Districts, Ethiopia
Low Dietary Diversity and Intake of Animal Source Foods among School Aged Children in Libo Kemkem and Fogera Districts, Ethiopia. Herrador Z, Pérez-Formigo J, Sordo L, Gadisa E, Moreno J, Benito A, Aseffa A, Custodio E. PLoS One. 2015 Jul 23;10(7):e0133435. doi: 10.1371/journal.pone.0133435. eCollection 2015.
PUBMED DOIEVALUACIÓN ECONÓMICA DE DISTINTAS ESTRATEGIAS PARA EL CRIBADO DE LA ENFERMEDAD DE CHAGAS EN ESPAÑA
EVALUACIÓN ECONÓMICA DE DISTINTAS ESTRATEGIAS PARA EL CRIBADO DE LA ENFERMEDAD DE CHAGAS EN ESPAÑA. Iñaki Imaz Iglesia, Lucía García San Miguel, Teresa Blasco Hernández, María Belén Martín Águeda, Jesús González-Enríquez, Lorenzo Eduardo Ayala Morillas, Lidia García Pérez, Antonio Sarría Santamera. AETS – Junio 2015. Edita: INSTITUTO DE SALUD CARLOS III. Ministerio de Economía y Competitividad NIPO en línea: 725150097 NIPO libro electrónico: 725150081.
PUBMED DOIUsing Hospital Discharge Database to Characterize Chagas Disease Evolution in Spain: There Is a Need for a Systematic Approach towards Disease Detection and Control.
Using Hospital Discharge Database to Characterize Chagas Disease Evolution in Spain: There Is a Need for a Systematic Approach towards Disease Detection and Control. Herrador Z, Rivas E, Gherasim A, Gómez-Barroso D, García J, Benito A, Aparicio P. PLoS Negl Trop Dis. 2015 Apr ;17;9(4):e0003710. doi:10.1371/journal.pntd.0003710
PUBMED DOIEpidemiological Changes in Leishmaniasis in Spain According to Hospitalization-Based Records, 1997-2011: Raising Awareness towards Leishmaniasis in Non-HIV Patients.
Epidemiological Changes in Leishmaniasis in Spain According to Hospitalization-Based Records, 1997-2011: Raising Awareness towards Leishmaniasis in Non-HIV Patients. Herrador Z, Gherasim A, Jiménez BC, Granados M, San Martín JV, Aparicio P. PLoS Negl Trop Dis. 2015 Mar 10;9(3)
PUBMED DOIHIV-1 infection using dried blood spots can be confirmed by Bio-Rad Geenius™ HIV 1/2 confirmatory assay
HIV-1 infection using dried blood spots can be confirmed by Bio-Rad Geenius™ HIV 1/2 confirmatory assay. Fernández McPhee C, Álvarez P, Prieto L, Obiang J, Avedillo P, Vargas A, Rojo P, Abad C, Ramos JT, Holguín A. J Clin Virol. 2015 Feb;63:66-9. doi: 10.1016/j.jcv.2014.12.018. Epub 2014 Dec 27.
PUBMED DOISpatial distribution and cluster analysis of a leishmaniasis outbreak in the south-western Madrid region, Spain, September 2009 to April 2013
Spatial distribution and cluster analysis of a leishmaniasis outbreak in the south-western Madrid region, Spain, September 2009 to April 2013. Gómez-Barroso D, Herrador Z, San Martín JV, Gherasim A, Aguado M, Romero-Maté A, Molina L, Aparicio P, Benito A. Euro Surveill. 2015 Feb 19;20(7):11-20.
PUBMED DOIMicronutrient deficiencies and related factors in school-aged children in ethiopia: a cross-sectional study in libo kemkem and fogera districts, amhara regional state.
Micronutrient deficiencies and related factors in school-aged children in ethiopia: a cross-sectional study in libo kemkem and fogera districts, amhara regional state. Herrador Z, Sordo L, Gadisa E, Buño A, Gómez-Rioja R, Iturzaeta JM, de Armas LF, Benito A, Aseffa A, Moreno J, Cañavate C, Custodio E. PLoS One. 2014 Dec 29;9(12):e112858.
PUBMED DOICross-sectional study of malnutrition and associated factors among school aged children in rural and urban settings of Fogera and Libo Kemkem districts, Ethiopia.
Cross-sectional study of malnutrition and associated factors among school aged children in rural and urban settings of Fogera and Libo Kemkem districts, Ethiopia. Herrador Z, Sordo L, Gadisa E, Moreno J, Nieto J, Benito A, Aseffa A, Cañavate C, Custodio E. PLoS One. 2014 Sep 29;9(9):e105880. doi: 10.1371/journal.pone.0105880. eCollection 2014.
PUBMED DOIKnowledge, attitudes and practices related to visceral leishmaniasis in rural communities of amhara state: a longitudinal study in northwest ethiopia.
Knowledge, attitudes and practices related to visceral leishmaniasis in rural communities of amhara state: a longitudinal study in northwest ethiopia. López-Perea N, Sordo L, Gadisa E, Cruz I, Hailu T, Moreno J, Aseffa A, Cañavate C, Custodio E. PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2799. doi: 10.1371/journal.pntd.0002799. eCollection 2014 Apr.
PUBMED DOIGlossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades
Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades. Cordón-Obras C, Cano J, Knapp J, Nebreda P, Ndong-Mabale N, Ncogo-Ada PR, Ndongo-Asumu P, Navarro M, Pinto J, Benito A, Bart JM. Parasit Vectors. 2014 Jan 17;7:31. doi: 10.1186/1756-3305-7-31.
PUBMED DOIInitial evaluation of a programme to prevent mother-to-child transmission of human immunodeficiency virus infection in Equatorial Guinea
Initial evaluation of a programme to prevent mother-to-child transmission of human immunodeficiency virus infection in Equatorial Guinea. Badillo-Navarro K, Prieto-Tato L, Obiang-Esomoyo J, Avedillo-Jiménez P, Vargas-Brizuela A, Rojo-Conejo P. Enferm Infecc Microbiol Clin. 2014 Jan;32(1):31-6. doi: 10.1016/j.eimc.2013.07.003. Epub 2013 Sep 27. Spanish.
PUBMED DOITrypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.
Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity. Cordón-Obras C, Cano J, González-Pacanowska D, Benito A, Navarro M, Bart JM. PLoS One. 2013 Dec 23;8(12):e85072. doi: 10.1371/journal.pone.0085072. eCollection 2013.
PUBMED DOILa basura tecnológica de la brecha digital. Nuevos contextos de contaminación ambiental
La basura tecnológica de la brecha digital. Nuevos contextos de contaminación ambiental. García B, Boquete T. Colegio Oficial de Biólogos de la Comunidad de Madrid 2013. (publicación enviada a la revista y aceptada)
Brecha digital y salud. Una aproximación a la realidad de Guinea Ecuatorial.
Brecha digital y salud. Una aproximación a la realidad de Guinea Ecuatorial. García B, Cubo S, Boquete T, Aparicio P. Programa Editorial del ISCIII, 2013
Epidemiology of soil-transmitted helminths, Schistosoma mansoni, and haematocrit values among schoolchildren in Ethiopia.
Epidemiology of soil-transmitted helminths, Schistosoma mansoni, and haematocrit values among schoolchildren in Ethiopia. Abera B, Alem G, Yimer M, Herrador Z: J Infect Dev Ctries; 2013 Mar;7(3):253-60.
Artesunate/amodiaquine malaria treatment for Equatorial Guinea (Central Africa).
Artesunate/amodiaquine malaria treatment for Equatorial Guinea (Central Africa). Charle P, Berzosa P, de Lucio A, Raso J, Nseng Nchama G, Benito A. Am J Trop Med Hyg. 2013 Jun;88(6):1087-92. doi: 10.4269/ajtmh.12-0290. Epub 2013 Mar 25.
PUBMED DOIGenetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea.
Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea. Mendes C, Salgueiro P, Gonzalez V, Berzosa P, Benito A, do Rosário VE, de Sousa B, Cano J, Arez AP. Malar J. 2013 Mar 27;12:114. doi: 10.1186/1475-2875-12-114.
PUBMED DOIBarriers and facilitators for exclusive breastfeeding in women’s biopsychosocial spheres according to primary care midwives in Tenerife (Canary Islands, Spain)
Llorente-Pulido S, Custodio E, López-Giménez MR, Sanz-Barbero B, and Otero-García L.Barriers and facilitators for exclusive breastfeeding in women’s biopsychosocial spheres according to primary care midwives in Tenerife (Canary Islands, Spain)Int. J. Environ. Res. Public Health 2021, 18, 3819.
ood and Nutrition Security Situtation Analysis in Selected Countries in support to the Pro-Resilience Action Programming for 2015.
Nkunzimana T, Custodio E, Thomas AC, Tefere N, Pérez-Hoyos A and Kayitakire F.Food and Nutrition Security Situtation Analysis in Selected Countries in support to the Pro-Resilience Action Programming for 2015.JRC Science and Policy Report, 2015.EUR 27879, doi:10.2788/669159.
Malnutrition and associated factors among school aged children in rural and urban settings in Libokemkem and Fogera, Ethiopia.
Herrador Z, Sordo L, Gadisa E, Moreno J, Nieto J, Benito A, Aseffa A, Cañavate C and Custodio E*. Malnutrition and associated factors among school aged children in rural and urban settings in Libokemkem and Fogera, Ethiopia.PLoS One Sep 29:e105880
Factors associated with visceral Leishmania asymptomatic infection: results from a cross-sectional survey in highland northern Ethiopia.
Custodio E*, Gadisa E, Sordo L, Cruz I, Moreno J, Nieto J, Chicharro C, Aseffa A, Abebe Z, Tsegaye H and Cañavate C.Factors associated with visceral Leishmania asymptomatic infection: results from a cross-sectional survey in highland northern Ethiopia.PLOS Neglected Tropical Diseases Sep 12, vol 6 (9), e1813.
Chagas screening and treatment among Bolivians living in Madrid, Spain:
Chagas screening and treatment among Bolivians living in Madrid, Spain: The need for an official protocol.María Romay-Barja, Teresa Boquete, Obdulia Martinez, Marlene González, Débora Álvarez-Del Arco, Agustín Benito, Teresa Blasco-Hernández PLoS One. 2019 Mar 8;14(3):e0213577.
PUBMED DOICaregivers' Malaria Knowledge, Beliefs and Attitudes, and Related Factors in the Bata District, Equatorial Guinea.
Caregivers' Malaria Knowledge, Beliefs and Attitudes, and Related Factors in the Bata District, Equatorial Guinea. Romay-Barja M, Ncogo P, Nseng G, Santana-Morales MA, Herrador Z, Berzosa P, Valladares B, Riloha M, Benito A. PLoS One. 2016 Dec 30;11(12):e0168668.
PUBMED DOIDeterminants of delay in malaria care-seeking behaviour for children 15 years and under in Bata district, Equatorial Guinea.
Determinants of delay in malaria care-seeking behaviour for children 15 years and under in Bata district, Equatorial Guinea.Maria Romay-Barja, Jorge Cano, Policarpo Ncogo, Gloria Nseng, Maria A. Santana-Morales, Basilio Valladares, Matilde Riloha and Agustin Benito Malar J. 2016 Mar 31;15:187.
PUBMED DOIMalaria Household Knowledge and Behavior in Equatorial Guinea: Lessons to be learned
Malaria Household Knowledge and Behavior in Equatorial Guinea: Lessons to be learned María Romay Barja (27/03/2019 19:44): Maria Romay-Barja, Jorge Cano, Jose Maria Ugarte, Jesus Roche, Gloria Nseng, Matilde Riloha, Agustin Benito and Estefanía Custodio J Infect Dis Preve Med 2016, 4:2
PUBMED DOIPrevalence of anemia and associated factors in children living in urban and rural settings from Bata District, Equatorial Guinea, 2013.
Prevalence of anemia and associated factors in children living in urban and rural settings from Bata District, Equatorial Guinea, 2013. Ncogo P, Romay-Barja M, Benito A, Aparicio P, Nseng G, Berzosa P, Santana-Morales MA, Riloha M, Valladares B, Herrador Z. PLoS One. 2017 May 3;12(5):e0176613. doi: 10.1371/journal.pone.0176613. eCollection 2017.
PUBMED DOISpatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea.
Spatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea. Gómez-Barroso D, García-Carrasco E, Herrador Z, Ncogo P, Romay-Barja M, Ondo Mangue ME, Nseng G, Riloha M, Santana MA, Valladares B, Aparicio P, Benito A. Malar J. 2017 Apr 12;16(1):146. doi: 10.1186/s12936-017-1794-z.
PUBMED DOIMediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. Herrador Z, Fernández-Martínez A, Gómez-Barroso D, León I, Vieira C, Muro A, Benito A. PLoS One. 2017 Mar 29;12(3):e0174745. doi: 10.1371/journal.pone.0174745. eCollection 2017
PUBMED DOIProfile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea).
Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea). Berzosa P, Esteban-Cantos A, García L, González V, Navarro M, Fernández T, Romay-Barja M, Herrador Z, Rubio JM, Ncogo P, Santana-Morales M, Valladares B, Riloha M, Benito A. Malar J. 2017 Jan 13;16(1):28. doi: 10.1186/s12936-016-1672-0.
PUBMED DOICaregivers' Malaria Knowledge, Beliefs and Attitudes, and Related Factors in the Bata District, Equatorial Guinea
Caregivers' Malaria Knowledge, Beliefs and Attitudes, and Related Factors in the Bata District, Equatorial Guinea. Romay-Barja M, Ncogo P, Nseng G, Santana-Morales MA, Herrador Z, Berzosa P, Valladares B, Riloha M, Benito A. PLoS One. 2016 Dec 30;11(12):e0168668. doi: 10.1371/journal.pone.0168668. eCollection 2016.
PUBMED DOIHigh prevalence of Strongyloides stercoralis in school-aged children in a rural highland of north-western Ethiopia: the role of intensive diagnostic work-up.
High prevalence of Strongyloides stercoralis in school-aged children in a rural highland of north-western Ethiopia: the role of intensive diagnostic work-up. Amor A, Rodríguez E, Saugar JM, Arroyo A, López-Quintana B, Abera B, Yimer M, Yizengaw E, Zewdie D, Ayehubizu Z, Hailu T, Mulu W, Echazú A, Krolewieki AJ, Aparicio P, Herrador Z, Anegagrie M, Benito A. Parasit Vectors. 2016 Dec 1;9(1):617.
PUBMED DOIInformación adicional
El Centro Nacional de Medicina Tropical (CNMT) aborda la investigación de las enfermedades tropicales desatendidas (ETDs), emergentes y re-emergentes desde un enfoque traslacional y con un equipo multidisciplinar. El CNMT realiza su trabajo tanto en España como en los países donde estas enfermedades son endémicas. A través de su programa de colaboración científico-técnica, el Centro apoya a los sistemas nacionales de salud en adquirir evidencia científica para la elaboración de las estrategias relacionadas con el control de estas enfermedades.
Además, el Centro Nacional de Medicina Tropical:
- Coordina la Red de Investigación Cooperativa en Enfermedades Tropicales (RICET) integrada por más de 20 grupos de excelencia españoles en investigación biomédica traslacional en enfermedades tropicales olvidadas .
- Fortalecimiento de la vigilancia epidemiológica en Guinea Ecuatorial, financiado por la AECID e implementado en colaboración con FERS y la FCSAI.
- Implementación de Planes de Mejora Continua para el manejo de Paludismo, VIH/SIDA y Tuberculosis a nivel hospitalario en las provincias de Litoral, Kie Ntem y Wele Nzás, Guinea Ecuatorial, financiado por la AECID.
- Apoyo Técnico al Laboratorio Nacional de Salud Pública en Guinea Ecuatorial Financiado por el Ministerio de Sanidad y Bienestar Social de la República de Guinea Ecuatorial. Project-Santé/BAD.